In-vitro activity of cephalosporins alone and combined with sulbactam against various strains of Acinetobacter baumannii with different antibiotic resistance profiles

• Published in: Journal of antimicrobial chemotherapy Vol. 37; no. 1; pp. 155 - 160
• Main Authors: Aubert, G., Guichard, D., Vedel, G.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.1996
• Subjects: Acinetobacter - drug effects; Acinetobacter baumannii; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; beta-Lactamases - metabolism; Biological and medical sciences; Cephalosporins - pharmacology; Drug Resistance, Microbial; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Sulbactam - pharmacology; Drug combination; Enzyme; Neisseriaceae; Enzyme inhibitor; β-Lactamase; In vitro; Acinetobacter baumannii; Antibiotic; Cephalosporin derivatives; Sensitivity resistance; Bacteria; Hydrolases; Micrococcales; Antibacterial agent
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/37.1.155

The β-lactamases of six strains of Acinetobacter baumannii were investigated using analytical isoelectric focusing, and the MIC values for 16 β-lactam antibiotics determined against the strains. Three strains produced a chromosomal cephalo sporinase (p1>8.5), one strain a CARB-5 β-lactamase (p1=6.35), one strain a TEM-1 penicillinase (p1=5.4) as well as a cephalosponnase (p1>8.5), and one carbapenem-resistant strain a β-lactamase with a p1>8.5. Ceftazidime, cefepime, cefpirome, imipenem and meropenem were found to be the most effective β-lactams against five strains. Sulbactam was active against four of the strains at 1-4 mg/L and showed enhanced killing effects with cefpirome.