Mutation profile of acute myeloid leukaemia in a Chinese cohort by targeted next‐generation sequencing

• Published in: Cancer reports Vol. 5; no. 10; pp. e1573 - n/a
• Main Authors: Lit, Benny Man Wai, Guo, Belinda B., Malherbe, Jacques A. J., Kwong, Yok Lam, Erber, Wendy N.
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley & Sons, Inc 01.10.2022; John Wiley and Sons Inc; Wiley
• Subjects: Chinese AML; Classification; DNMT3A; Genes; Genomes; Invoices; Leukemia; Mutation; mutation frequency; next‐generation sequencing; Original; Patients

Background Acute myeloid leukaemia (AML) results from the clonal expansion of blast cells of myeloid origin driven by genomic defects. The advances in next‐generation sequencing (NGS) have allowed the identification of many mutated genes important in the pathogenesis of AML. Aims In this study, we a...