Multiple symmetric lipomatosis (Launois-Bensaude syndrome): effect of oral salbutamol

• Published in: Clinical endocrinology (Oxford) Vol. 27; no. 5; p. 601
• Main Authors: Leung, N W, Gaer, J, Beggs, D, Kark, A E, Holloway, B, Peters, T J
• Format: Journal Article
• Language: English
• Published: England 01.11.1987
• Subjects: Administration, Oral; Adrenergic beta-Agonists - pharmacology; Aged; Albuterol - administration & dosage; Albuterol - therapeutic use; Cyclic AMP - metabolism; Humans; Lipolysis - drug effects; Lipomatosis - drug therapy; Lipomatosis, Multiple Symmetrical - drug therapy; Lipomatosis, Multiple Symmetrical - metabolism; Male
• ISSN: 0300-0664
• DOI: 10.1111/j.1365-2265.1987.tb01190.x

A 65-year-old Kenyan Asian developed rapidly progressive multiple symmetrical lipomatosis over 8 years. Noradrenaline infusion showed a normal response of plasma free fatty acids. In-vitro studies of the lipomatous tissue demonstrated intact lipolytic activities with a normal rate of free fatty acids release and cyclic AMP accumulation with or without isoprenaline and fenoterol stimulation. A clinical trial of oral salbutamol, a beta 2-agonist, was performed with significant therapeutic effect. The body fat mass showed a reversal of the rapid progression while on the treatment, associated with an increase in the resting metabolic rate.