T594M mutation of the epithelial sodium channel β‐subunit gene in pre‐eclampsia and eclampsia in Black South African women
The possible role of the β‐subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre‐eclampsia (n= 204), early onset pre‐eclampsia (n= 67), eclampsia (n= 120) and gestational hypert...
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Published in | BJOG : an international journal of obstetrics and gynaecology Vol. 111; no. 9; pp. 1012 - 1013 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK and Malden, USA
Blackwell Science Ltd
01.09.2004
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | The possible role of the β‐subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre‐eclampsia (n= 204), early onset pre‐eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full‐term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of the various patient groups and in 3.6% of the control group reflecting no significant difference. These results suggest that the T594M polymorphism in the sodium channel β‐subunit is not associated with the pathogenesis of pre‐eclampsia or gestational hypertension. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1470-0328 1471-0528 |
DOI: | 10.1111/j.1471-0528.2004.00221.x |