Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

• Published in: Journal of food science Vol. 83; no. 1; pp. 6 - 16
• Main Authors: Admassu, Habtamu, Gasmalla, Mohammed Abdalbasit. A., Yang, Ruijin, Zhao, Wei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: Algae; Angiotensin; antidiabetic properties; antihypertensive effect; Antihypertensives; antioxidant activity; Antioxidants; bioactive peptides; Biological activity; Cardiovascular diseases; death; Diabetes; Diabetes mellitus; digestion; Disease control; enzyme inhibition; Food; food industry; functional foods; Functional foods & nutraceuticals; Health; Hypertension; hypoglycemic agents; In vivo methods and tests; in vivo studies; isolation techniques; macroalgae; Oxidative stress; Peptides; Peptidyl-dipeptidase A; Pharmaceuticals; Prevention; Protein sources; Proteins; seaweed; Seaweeds; antihypertensive effect; seaweed; bioactive peptides; antidiabetic properties; antioxidant activity
• ISSN: 0022-1147; 1750-3841; 1750-3841
• DOI: 10.1111/1750-3841.14011

Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein‐derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide‐based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large‐scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.