Preoperative tumour staging with multidisciplinary team assessment improves the outcome in locally advanced primary rectal cancer

• Published in: Colorectal disease Vol. 13; no. 12; pp. 1361 - 1369
• Main Authors: Palmer, G., Martling, A., Cedermark, B., Holm, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2011
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Chemoradiotherapy, Adjuvant; Female; Humans; Kaplan-Meier Estimate; local recurrence; locally advanced primary rectal cancer; Male; Medicin och hälsovetenskap; Middle Aged; multidisciplinary conference; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Staging; Neoplasm, Residual; Patient Care Team; Preoperative Care; Preoperative evaluation; Radiotherapy, Adjuvant; Rectal Neoplasms - diagnosis; Rectal Neoplasms - therapy; survival; Treatment Outcome
• ISSN: 1462-8910; 1463-1318; 1463-1318
• DOI: 10.1111/j.1463-1318.2010.02460.x

Aim  Multidisciplinary team meetings have been introduced as a result of developments in preoperative radiological tumour staging and neoadjuvant treatment. Multidisciplinary team recommendations will influence treatment decisions but their effect on patient outcome is unknown. The aim of this study was to assess outcome in relation to preoperative local and distant staging, with or without multidisciplinary team assessment. Methods  A population‐based registry of all patients with rectal cancer, treated in the Stockholm region from 1995 to 2004, identified 303 patients with locally advanced primary rectal cancer. The patients were classified into three groups: group 1, preoperative local and distant radiological tumour staging with discussion at a multidisciplinary team meeting; group 2, preoperative staging but no multidisciplinary team assessment; and group 3, no proper preoperative radiological staging. Results  Neoadjuvant treatment was more prevalent in groups 1 and 2 than in group 3. The incidence of R0 resection differed significantly between the groups (52% in group 1, 43% in group 2 and 21% in group 3; P < 0.001). Local tumour control was achieved in 57%, 36%, and 19% of patients in groups 1, 2 and 3, respectively (P < 0.001). The estimated overall 5‐year survival of patients was 30%, 28% and 12% in groups 1, 2 and 3, respectively. Conclusion  Preoperative radiological tumour staging in patients with locally advanced primary rectal cancer and discussion at a multidisciplinary team meeting increases the proportion of patients receiving neoadjuvant treatment and cancer‐specific end‐points.