Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia

• Published in: The American journal of clinical nutrition Vol. 56; no. 1; pp. 93 - 98
• Main Authors: Anderson, JW, Riddell-Mason, S, Gustafson, NJ, Smith, SF, Mackey, M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1992; American Society for Clinical Nutrition
• Subjects: ABSORCION DE SUBSTANCIAS NUTRITIVAS; ABSORPTION DE SUBSTANCES NUTRITIVES; administration & dosage; ADULTE; ADULTOS; adults; analysis; Anticholesteremic Agents; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - therapeutic use; antilipemic agents; Apolipoprotein A-I; Apolipoprotein A-I - analysis; apolipoproteins; Apolipoproteins B; Apolipoproteins B - blood; Biological and medical sciences; BLE; blood; blood serum; Body Weight; breakfast cereals; CEREALE POUR PETIT DEJEUNER; CEREALES PARA DESAYUNO; Chemotherapy, Adjuvant; CHOLESTEROL; Cholesterol, LDL; Cholesterol, LDL - blood; COLESTEROL; COMPLEMENTATION; diet therapy; DIETA; Dietary Fats; Dietary Fats - administration & dosage; dietary fiber; Dietary Fiber - administration & dosage; Dietary Fiber - therapeutic use; dietary supplements; Disorders of blood lipids. Hyperlipoproteinemia; Double-Blind Method; drug therapy; Edible Grain; ENERGIA; ENERGIE; energy intake; ENRIQUECIMIENTO DE LOS ALIMENTOS; experimental diets; EXPERIMENTATION; EXPERIMENTOS; Female; FIBRA DE LA DIETA; FIBRE ALIMENTAIRE; high density lipoprotein; Humans; hypercholesterolemia; Hypercholesterolemia - diet therapy; Hypercholesterolemia - drug therapy; LIPOPROTEINAS; LIPOPROTEINE; low density lipoprotein; Male; Medical sciences; MEDICAMENT; MEDICAMENTOS; Metabolic diseases; MUCILAGE; mucilages; MUCILAGOS; nutrient intake; Patient Compliance; Psyllium; Psyllium - administration & dosage; Psyllium - therapeutic use; ready-to-eat cereal; REGIME ALIMENTAIRE; safety; SALVADO; serum cholesterol; serum lipids; SERUM SANGUIN; SON; SUERO SANGUINEO; therapeutic use; tolerance; TRASTORNOS METABOLICOS; triacylglycerols; TRIGLICERIDOS; TRIGLYCERIDE; TRIGO; TROUBLE DU METABOLISME; wheat bran; Psyllium; serum cholesterol; safety; ready-to-eat cereal; serum lipids; hypercholesterolemia; tolerance; Human; Hypercholesterolemia; Diet therapy; Diet; Metabolic diseases; Cereal; Lipids; Hyperlipemia; Dietary fiber; Metabolism; Cholesterol
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/56.1.93

Psyllium hydrophilic mucilloid, rich in soluble fiber, significantly lowers serum cholesterol concentrations. To investigate the lipid-lowering effects of a ready-to-eat cereal enriched with psyllium, we studied 44 hypercholesterolemic ambulatory individuals for 7 wk, using a randomized, double-blind, parallel design. After a 1-wk baseline period, subjects were randomly assigned to consume 114 g/d of a psyllium-flake or wheat-bran-flake cereal for 6 wk adjunctive to an American Heart Association Step I diet. Serum high-density-lipoprotein cholesterol and triglycerides remained unchanged throughout the study; however, serum cholesterol and low-density lipoprotein (LDL) concentrations were significantly lower on psyllium than on wheat-bran cereal. Additionally, serum total and LDL cholesterol values were significantly lower than baseline values in the psyllium group. The dietary nutrient intake of the two groups did not differ except for soluble fiber. Adding psyllium-enriched cereal to a prudent low-fat diet may enhance dietary management of hypercholesterolemia.