Quantitative Comparison of Angiographic Characteristics of Coronary Artery Disease in Patients With Noninsulin-Dependent Diabetes Mellitus Compared With Matched Nondiabetic Control Subjects

• Published in: The American journal of cardiology Vol. 80; no. 5; pp. 550 - 556
• Main Authors: Pajunen, Pia, Nieminen, Markku S., Taskinen, Marja-Riitta, Syvänne, Mikko
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1997; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Coronary Angiography; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - pathology; Coronary heart disease; Coronary vessels; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Exercise Test; Female; Heart; Humans; Male; Matched-Pair Analysis; Medical research; Medical sciences; Middle Aged; Retrospective Studies; Endocrinopathy; Human; Radiodiagnosis; Angiography; Cardiovascular disease; Exploration; Coronary heart disease; Non insulin dependent diabetes; Comparative study; Quantitative analysis
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(97)00420-7

The angiographic characteristics of coronary artery disease (CAD) in noninsulin-dependent diabetes mellitus (NIDDM) patients were studied by quantitative coronary angiography (QCA). Fifty-seven consecutive NIDDM patients undergoing clinically indicated elective coronary angiography and 57 nondiabetic coronary artery disease (CAD) patients were individually matched for sex, age, and body mass index. Technically adequate coronary angiograms, available for 55 subjects in each group, were analyzed with third-generation QCA software. To evaluate the anatomic severity and extent of CAD, several QCA-derived parameters were incorporated into indexes describing various per-patient features of CAD. These measures reflect CAD severity, extent, and overall “atheroma burden,” and were calculated separately for different coronary segments (i.e., left main, proximal, mid, and distal segments), for the different coronary arterial territories (i.e., left main, left anterior descending, left circumflex, and right), and for the entire coronary tree. No significant differences were found between the NIDDM and nondiabetic groups (global severity index, 51 ± 14 vs 54 ± 13, p = NS; global extent index, 34 ± 13 vs 32 ± 12, p = NS; global atheroma burden index, 27 ± 16 vs 24 ± 12, p = NS). We also found no between-group differences in proximal, mid, or distal segments, in separate vessel territories, or in left ventricular function. Our data suggest that CAD patients, with and without NIDDM, who have similar symptoms at a given age, have similar severity and extent of CAD.