Sex difference in the expression of PD-1 of non-small cell lung cancer
Evidence increasingly indicated that lung cancer incidence in female individuals continue to rise, and women have a higher risk to develop adenocarcinoma than men. Male and female individuals differ in their innate and adaptive immune responses, and there are sex differences in response to the PD-1/...
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Published in | Frontiers in immunology Vol. 13; p. 1026214 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
20.10.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Evidence increasingly indicated that lung cancer incidence in female individuals continue to rise, and women have a higher risk to develop adenocarcinoma than men. Male and female individuals differ in their innate and adaptive immune responses, and there are sex differences in response to the PD-1/PD-L1-dependent blocking immunotherapy. Whether the differential expression of PD-1 between genders affect the response to blocking treatment is currently unknown. In this study, we examined sex differences in serum sPD-1, mPD-1 expression on T cells, and sex hormone levels in non-small cell lung cancer (NSCLC) patients. Our results revealed a higher level of sPD-1 and expression of PD-1 on CD4+T cell in female patients than in male patients; we identified that serum sPD-1 level and the expression of mPD-1 on T cells were significantly reduced in NSCLC; we also found that serum testosterone level increased in female patients compared with control subjects and that increased testosterone downregulated the expression of mPD-1 on T cell. These findings provide a better understanding of the differences in PD-1 expression between genders in NSCLC patients and the effect of sex hormones on PD-1 expression and supply evidence for early lung cancer diagnosis and responsiveness to immune checkpoint inhibitors. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Chengzhi Zhou, Clinical Management Department of National Respiratory Medical Center, China; Elena Gershtein, Russian Cancer Research Center NN Blokhin, Russia Present addresses: Chuan G. Lu, Department of Thoracic Surgery, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province; ChinaSi Y. Sheng, Department of Thoracic Surgery, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, China These authors have contributed equally to this work and share first authorship Edited by: Liting Chen, Huazhong University of Science and Technology, China This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2022.1026214 |