Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation

• Published in: Bulletin of experimental biology and medicine Vol. 167; no. 6; pp. 787 - 790
• Main Authors: Kondrat’eva, D. S., Afanas’ev, S. A., Archakov, E. A., Tsapko, L. P., Batalov, R. E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2019; Springer
• Subjects: Adult; Atrial fibrillation; Atrial Fibrillation - diagnostic imaging; Atrial Fibrillation - metabolism; Atrial Fibrillation - pathology; Atrial Fibrillation - physiopathology; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Biopsy; Blood Flow Velocity; Care and treatment; Cell Biology; Echocardiography; Experimental Methods for Clinical Practice; Female; Heart; Heart Atria - metabolism; Heart Atria - pathology; Heart Ventricles - physiopathology; Humans; Internal Medicine; Laboratory Medicine; Male; Middle Aged; Myocardium - metabolism; Myocardium - pathology; Pathology; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; Ventricular Function, Left - physiology; atrial fibrillation; echocardiography; SERCA2a expression
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04623-9

The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic volume, and end-diastolic volume. In contrast, SERCA2a expression negatively correlated with early (peak E) and late (peak A) diastolic filling rates in left ventricle. SERCA2a expression was also associated with echocardiographic parameters reflecting structural and functional status of the heart in patients with persistent atrial fibrillation.