Chromosomal aberrations in uranium and coal miners

• Published in: International journal of radiation biology Vol. 80; no. 2; pp. 147 - 153
• Main Authors: Wolf, G., Arndt, D., Kotschy-Lang, N., Obe, G.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.02.2004; Taylor & Francis
• Subjects: Adult; Aged; Alcohol Drinking; Case-Control Studies; Chromatids - ultrastructure; Chromosome Aberrations; Chromosomes - ultrastructure; Coal Mining; Cytogenetics; DNA Damage; Humans; Male; Metaphase - drug effects; Middle Aged; Mining; Occupational Exposure; Radiation, Ionizing; Sister Chromatid Exchange; Smoking; Time Factors; Uranium; Germany
• ISSN: 0955-3002; 1362-3095
• DOI: 10.1080/09553000310001621446

Purpose: To compare chromosomal aberrations in peripheral lymphocytes of Wismut uranium miners (WUM) and Ruhr coal miners (RCM). Materials and methods: Peripheral lymphocytes from 66 WUM and 29 RCM were cultured and analysed for structural chromosomal aberrations in Giemsa-stained M1 metaphases. Cytogenetic data from 23 male white-collar workers from public services were used as a historical control group. Results: The frequencies of chromosomal aberrations and sister chromatid exchanges in WUM and RCM were quite similar. Compared with public services workers, WUM and RCM had significantly higher frequencies of chromosomal aberrations. Conclusions: Chromosomal aberrations in WUM are not induced by radioactive particles inhaled during underground mining but as in RCM rather result from factors such as age, lifestyle, illnesses, medications and diagnostic irradiations.