Circular RNAs in diabetes and its complications: Current knowledge and future prospects

A novel class of non-coding RNA transcripts called circular RNAs (circRNAs) have been the subject of significant recent studies. Accumulating evidence points that circRNAs play an important role in the cellular processes, inflammatory expression, and immune responses through sponging miRNA, binding,...

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Published inFrontiers in genetics Vol. 13; p. 1006307
Main Authors Yin, Wenfeng, Zhang, Ziwei, Xiao, Zilin, Li, Xia, Luo, Shuoming, Zhou, Zhiguang
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 26.10.2022
Subjects
biomarkers
circular RNAs
diabetes
diabetic complication
Genetics
type 1 diabetes
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Summary:A novel class of non-coding RNA transcripts called circular RNAs (circRNAs) have been the subject of significant recent studies. Accumulating evidence points that circRNAs play an important role in the cellular processes, inflammatory expression, and immune responses through sponging miRNA, binding, or translating in proteins. Studies have found that circRNAs are involved in the physiologic and pathologic processes of diabetes. There has been an increased focus on the relevance of between abnormal circRNA expression and the development and progression of various types of diabetes and diabetes-related diseases. These circRNAs not only serve as promising diagnostic and prognostic molecular biomarkers, but also have important biological roles in islet cells, diabetes, and its complications. In addition, many circRNA signaling pathways have been found to regulate the occurrence and development of diabetes. Here we comprehensively review and discuss recent advances in our understanding of the physiologic function and regulatory mechanisms of circRNAs on pancreatic islet cells, different subtypes in diabetes, and diabetic complications.
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Hamed Shoorei, Birjand University of Medical Sciences, Iran
Reviewed by: Amaresh Chandra Panda, Institute of Life Sciences (ILS), India
These authors have contributed equally to this work and share first authorship
Edited by: Tingxiang Yan, Mayo Clinic Florida, United States
This article was submitted to RNA, a section of the journal Frontiers in Genetics
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2022.1006307