Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers

In this study, investigators compared genome sequencing with cytogenetic analysis in 263 patients with acute myeloid leukemia or myelodysplastic syndromes. Prospective sequencing detected new genetic information that was not revealed by cytogenetic analysis in nearly 25% of the patients, which alter...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 384; no. 10; pp. 924 - 935
Main Authors Duncavage, Eric J, Schroeder, Molly C, O’Laughlin, Michele, Wilson, Roxanne, MacMillan, Sandra, Bohannon, Andrew, Kruchowski, Scott, Garza, John, Du, Feiyu, Hughes, Andrew E.O, Robinson, Josh, Hughes, Emma, Heath, Sharon E, Baty, Jack D, Neidich, Julie, Christopher, Matthew J, Jacoby, Meagan A, Uy, Geoffrey L, Fulton, Robert S, Miller, Christopher A, Payton, Jacqueline E, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, DiPersio, John F, Ley, Timothy J, Spencer, David H
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 11.03.2021
Subjects
Acute myeloid leukemia
Algorithms
Bone marrow
Cancer
Cancer research
Cytogenetic Analysis
Cytogenetics
Feasibility Studies
Female
Genes
Genomes
Genomic analysis
Humans
Laboratories
Leukemia
Leukemia, Myeloid, Acute - genetics
Male
Middle Aged
Mutation
Myelodysplastic syndrome
Myelodysplastic syndromes
Myelodysplastic Syndromes - genetics
Myeloid leukemia
Patients
Proportional Hazards Models
Risk groups
Statistical analysis
Survival Analysis
Translocation
Whole genome sequencing
Whole Genome Sequencing - methods
Online AccessGet full text

Cover

More Information
Summary:In this study, investigators compared genome sequencing with cytogenetic analysis in 263 patients with acute myeloid leukemia or myelodysplastic syndromes. Prospective sequencing detected new genetic information that was not revealed by cytogenetic analysis in nearly 25% of the patients, which altered the risk category for most of these patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2024534