Inorganic-Organic Magnetic Nanocomposites for use in Preventive Medicine: A Rapid and Reliable Elimination System for Cesium

• Published in: Pharmaceutical research Vol. 29; no. 5; pp. 1404 - 1418
• Main Authors: Namiki, Yoshihisa, Namiki, Tamami, Ishii, Yukiko, Koido, Shigeo, Nagase, Yuki, Tsubota, Akihito, Tada, Norio, Kitamoto, Yoshitaka
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2012; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Carcinogens, Environmental - chemistry; Cattle; Cesium - analysis; Cesium - blood; Cesium - chemistry; Cesium - metabolism; Cesium Radioisotopes - analysis; Cesium Radioisotopes - blood; Cesium Radioisotopes - chemistry; Cesium Radioisotopes - metabolism; Drug Stability; Ferrocyanides - chemistry; Hydrogen-Ion Concentration; Inorganic chemistry; Magnetics; Medical Law; Milk - chemistry; Nanocomposites; Organic chemistry; Pharmacology/Toxicology; Pharmacy; Preventive Medicine; Research Paper; Seawater - chemistry; Spectroscopy, Fourier Transform Infrared; Surface Properties; Time Factors; Vaccinium; X-Ray Diffraction; Prussian blue; cesium; magnetic nanoparticles; seawater; magnetic elimination; biological matrix
• ISSN: 0724-8741; 1573-904X
• DOI: 10.1007/s11095-011-0628-x

Purpose To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed “Prussian blueberry”, to bring about the magnetic elimination of cesium. Methods Prussian blueberry were prepared by a layer-by-layer assembly method. The morphology, structure and physical properties of the Prussian blueberry were investigated as was their ability to magnetically eliminate cesium. Results We confirmed that Prussian blueberry were composed of a magnetite nanoparticle-core and a Prussian blue-shell. Under a magnetic field, Prussian blueberry (5 mg) reduced the cesium concentration of seawater (3 ml) from 150 ppm to about 50 ppm; but regular Prussian blue could not magnetically eliminate cesium. Moreover, Prussian blueberry removed a similar proportion of cesium from a larger volume of seawater, and from fetal bovine serum and cow’s milk. Conclusions Under a magnetic field, Prussian blueberry was able to rapidly eliminate cesium from seawater and from biological matrices such as serum and milk.