Changes in carbohydrate composition in human milk over 4 months of lactation

This study aimed to examine the carbohydrate content (monosaccharides, lactose, and oligosaccharides) of human milk over 4 months of lactation to determine whether any changes occurred over time. Milk samples from 46 mothers, who delivered at term, were collected at 4th, 10th, 30th, 60th, 90th, and...

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Bibliographic Details
Published inPediatrics (Evanston) Vol. 91; no. 3; p. 637
Main Authors Coppa, G V, Gabrielli, O, Pierani, P, Catassi, C, Carlucci, A, Giorgi, P L
Format Journal Article
LanguageEnglish
Published United States 01.03.1993
Subjects
Carbohydrates - analysis
Female
Humans
Lactation - metabolism
Lactose - analysis
Milk, Human - chemistry
Monosaccharides - analysis
Oligosaccharides - analysis
Time Factors
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Summary:This study aimed to examine the carbohydrate content (monosaccharides, lactose, and oligosaccharides) of human milk over 4 months of lactation to determine whether any changes occurred over time. Milk samples from 46 mothers, who delivered at term, were collected at 4th, 10th, 30th, 60th, 90th, and 120th days after delivery. Carbohydrates were measured by high-pressure liquid chromatography. Mean lactose concentration (+/- SD) increased from 56 +/- 6.06 g/L on day 4 to 68.9 +/- 8.16 g/L on day 120. Oligosaccharide level decreased from 20.9 +/- 4.81 g/L to 12.9 +/- 3.30 g/L, respectively. Monosaccharides represented only 1.2% of total carbohydrates. The changes in carbohydrate composition found indicate that carbohydrate synthesis by the mammary gland is a dynamic process. The physiological and biological relevance of human milk oligosaccharides is also discussed.
ISSN:0031-4005
DOI:10.1542/peds.91.3.637