Bisphenol A and phthalates exhibit similar toxicogenomics and health effects

Plastics are widely used in modern life, and their unbound chemicals bisphenol A and phthalates can leach out into the surrounding environment. BPA and PAEs have recently attracted the special attention of the scientific community, regulatory agencies and the general public because of their high pro...

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Bibliographic Details
Published inGene Vol. 494; no. 1; pp. 85 - 91
Main Authors Singh, Sher, Li, Steven Shoei-Lung
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.02.2012
Subjects
adverse effects
Benzhydryl Compounds
biomarkers
Bisphenol A
Databases as Topic
Diseases
Environmental Exposure
Genes
human health
Humans
inflammation
Inflammation - chemically induced
Phenols - toxicity
Phthalates
Phthalic Acids - toxicity
plastics
Proteins
toxicity
Toxicogenetics
Toxicogenomics
MEHP
Genes
GO
Toxicogenomics
Phthalates
Diseases
Proteins
BBP
Bisphenol A
BPA
CTD
DBP
DEHP
MBP
IPA
PVC
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Summary:Plastics are widely used in modern life, and their unbound chemicals bisphenol A and phthalates can leach out into the surrounding environment. BPA and PAEs have recently attracted the special attention of the scientific community, regulatory agencies and the general public because of their high production volume, widespread use of plastics, and endocrine-disrupting effects. In The Comparative Toxicogenomics Database, BPA and five most frequently curated PAEs (DEHP/MEHP and DBP/BBP/MBP) were found to have 1932 and 484 interactions with genes/proteins, respectively. Five of their top ten toxicity networks were found to be involved in inflammation, and their top ten diseases included genital, prostatic, endomentrial, ovarian and breast diseases. BPA and PAEs were found to exhibit similar toxicogenomics and adverse effects on human health owning to their 89 common interacting genes/proteins. These 89 genes/proteins may serve as biomarkers to assay the toxicities of different chemicals leached out from the widely used plastics. ► Toxicogenomics and disease association of 1,232 BPA-interacting genes/proteins. ► Comparative toxicogenomics and health effects between BPA and PAEs. ► BPA and PAEs were found to exhibit similar toxicogenomics and adverse effects. ► These 89 common interacting genes/proteins of BPA and PAEs were found. ► The 89 common genes/proteins may serve as biomarkers.
Bibliography:http://dx.doi.org/10.1016/j.gene.2011.11.035
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2011.11.035