The central role of Sertoli cells in spermatogenesis

Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules. The regulation of spermat...

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Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 9; no. 4; pp. 411 - 416
Main Author Griswold, Michael D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1998
Subjects
Animals
FSH, germ cells, Sertoli cells, testosterone, transferrin
Humans
Male
Sertoli Cells - cytology
Sertoli Cells - physiology
Spermatogenesis - physiology
FSH, germ cells, Sertoli cells, testosterone, transferrin
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Summary:Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules. The regulation of spermatogenesis by FSH and testosterone occurs by the action of these hormones on the Sertoli cells. While the action of testosterone is necessary for spermatogenesis, the action of FSH minimally serves to promote spermatogenic output by increasing the number of Sertoli cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1084-9521
1096-3634
DOI:10.1006/scdb.1998.0203