The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis

• Published in: Cancer letters Vol. 377; no. 1; pp. 87 - 96
• Main Authors: Kuang, Xia-Ying, Jiang, He-Sheng, Li, Kai, Zheng, Yi-Zi, Liu, Yi-Rong, Qiao, Feng, Li, Shan, Hu, Xin, Shao, Zhi-Ming
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.07.2016; Elsevier Limited
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cell growth; Cell Line, Tumor; Cell Movement; Conflicts of interest; Decision Support Techniques; Disease-Free Survival; Female; GRP78; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Hematology, Oncology and Palliative Medicine; Humans; Immunoglobulins; Kaplan-Meier Estimate; Kinases; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - secondary; MAP Kinase Kinase Kinases - metabolism; Medical prognosis; Metastasis; Mice, Nude; Neoplasm Invasiveness; Neoplasm Staging; Phosphorylation; Proportional Hazards Models; Protein Binding; Protein expression; Proteins; Risk Assessment; Risk Factors; RNA Interference; Serine; Signal Transduction; Stathmin; Stathmin - genetics; Stathmin - metabolism; Time Factors; Transfection; Stathmin; GRP78; breast cancer; metastasis; phosphorylation; Phosphorylation; Breast cancer; Metastasis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.04.035

High Lights • Specific STMN1 phosphorylation patterns associated with breast cancer metastasis. • GRP78 is a phospho-Ser25/Ser38 STMN1-binding protein • Binding of Phospho-STMN1 to GRP78 is regulated by MEK kinase • Integration of p-STMN1/GRP78 signatures predict clinical outcomes in breast cancer