Bilateral erector spinae plane block by multiple injection for pain control in pseudomyxoma peritonei surgery: a single-blind randomized controlled trial

• Published in: BMC anesthesiology Vol. 24; no. 1; pp. 370 - 9
• Main Authors: Yu, Shuang, Gao, Guangya, Ma, Ruiqing, Lu, Liangyuan, Zhao, Yaoping, Yang, Zhanmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.10.2024; BioMed Central; BMC
• Subjects: Abdomen; Adult; Aged; Analgesia; Analgesics; Analgesics, Opioid - administration & dosage; Anesthesia; Anesthesia, General - methods; Anesthetics, Local - administration & dosage; Blood pressure; Cancer; Care and treatment; Chemotherapy; Clinical trials; Diaphragm (Anatomy); Drug dosages; Epidural; Erector spinae plane block; Extubation; Female; General anesthesia; Hematoma; Humans; Injection; Male; Medical personnel; Middle Aged; Narcotics; Nausea; Nerve Block - methods; Opioids; Pain; Pain management; Pain Management - methods; Pain Measurement - methods; Pain perception; Pain, Postoperative - prevention & control; Paraspinal Muscles; Patients; Peritoneal Neoplasms - therapy; Postoperative analgesia; Pseudomyxoma peritonei; Pseudomyxoma Peritonei - surgery; Pseudomyxoma Peritonei - therapy; Regional anesthesia; Remifentanil; Ropivacaine; Single-Blind Method; Sufentanil; Surgery; Thoracic surgery; Ultrasonic imaging; Ultrasound-guided; Variance analysis; Vomiting; Erector spinae plane block; Regional anesthesia; Ultrasound-guided; Postoperative analgesia; Pseudomyxoma peritonei
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-024-02749-6

Currently, the primary surgical treatment for pseudomyxoma peritonei (PMP) is cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). The perioperative period is frequently accompanied by severe pain. Erector spinae plane block (ESPB) can enhance analgesia for abdominal surgery. The purpose of this study was to compare the analgesic effects of bilateral multiple-injection ESPB in patients with PMP. Fifty patients with PMP were randomly divided into two groups: the ESPB combined with general anesthesia group (Group E) and the general anesthesia alone group (Group C). Prior to the induction, patients in Group E underwent ESPB at the T7 and T11 levels. The primary outcome was the visual analog scale (VAS) scores during rest at 6 h post-extubation. Secondary outcomes included intraoperative and postoperative opioid consumption, time for first rescue analgesia, frequency distribution of rescue analgesia, incidence of nausea and vomiting, adverse events associated with ESPB. The Visual Analogue Scale (VAS) scores in Group E were significantly lower compared to Group C at immediate post-extubation (1.6 ± 0.9 vs. 2.4 ± 1.2, P = 0.008), and at 2 (1.9 ± 1.2 vs. 3.2 ± 1.1, P < 0.001), 4 (2.4 ± 1.5 vs. 3.7 ± 1.0, P = 0.001), and 6 h (2.7 ± 1.1 vs. 3.8 ± 1.4, P = 0.004) post-extubation during rest. Similarly, the VAS scores in Group E were significantly lower than those in Group C at immediate post-extubation (3.0 ± 1.4 vs. 4.6 ± 1.2, P < 0.001), and at 2 (3.8 ± 1.7 vs. 4.9 ± 1.4, P = 0.019), 4 (3.5 ± 1.3 vs. 5.3 ± 1.5, P < 0.001), and 6 h (3.9 ± 1.8 vs. 4.9 ± 1.3, P = 0.004) post-extubation during movement. In Group E, the intraoperative remifentanil administration (2319.3 ± 1089.5 vs. 2984.6 ± 796.1, P = 0.017) and the amount of rescue analgesia within 2 h post-extubation (0 vs. 4, P = 0.037) were significantly less than in Group C, and the first rescue analgesia time was shorter as well (231.4 ± 147.5 vs. 668.8 ± 416.7, P < 0.001). Compared to general anesthesia alone, bilateral multiple-injection ESPB with 0.2% ropivacaine can enhance analgesia and reduce opioid administration in patients with PMP. However, the duration of analgesia with ESPB is relatively short due to the low concentration of the local anesthetic used. Chinese Clinical Trial Registry, ChiCTR2300069504, 20/03/2023.