Lysine, a Precursor of Carnitine in the Rat

Rats, fed a 20% gluten diet in which lysine is the limiting amino acid, exhibited a reduction of growth, anemia, and hypoproteinemia. Carnitine concentrations in skeletal muscle and heart of such lysine-deficient rats were significantly lower than in rats supplemented with 0.8% lysine, but were high...

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Published inThe Journal of biological chemistry Vol. 246; no. 20; pp. 6364 - 6366
Main Authors Tanphaichitr, V, Horne, D W, Broquist, H P
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 25.10.1971
Subjects
Anemia
Animals
Blood Proteins - analysis
Body Weight
Carbon Isotopes
Carnitine - biosynthesis
Chromatography, Ion Exchange
Diet
Hematocrit
Hemoglobins - analysis
Hypoproteinemia
Liver - metabolism
Lysine - metabolism
Male
Models, Biological
Muscles - metabolism
Myocardium - metabolism
Rats
Rats, Inbred Strains
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Summary:Rats, fed a 20% gluten diet in which lysine is the limiting amino acid, exhibited a reduction of growth, anemia, and hypoproteinemia. Carnitine concentrations in skeletal muscle and heart of such lysine-deficient rats were significantly lower than in rats supplemented with 0.8% lysine, but were higher in the liver. Following intraperitoneal administration in lysine-deficient rats, radioactivity from dl -[6- 14 C]lysine, but not dl -[2- 14 C]lysine, was significantly incorporated into carnitine in the liver and skeletal muscle. These data thus establish a role for lysine in carnitine biosynthesis in the rat. A hypothetical scheme postulating transformations of lysine to yield carnitine is considered.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9258
1083-351X
DOI:10.1016/s0021-9258(18)61799-5