Triglyceride–glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: The Vascular-Metabolic CUN cohort

• Published in: Preventive medicine Vol. 86; pp. 99 - 105
• Main Authors: Navarro-González, David, Sánchez-Íñigo, Laura, Pastrana-Delgado, Juan, Fernández-Montero, Alejandro, Martinez, J. Alfredo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2016
• Subjects: Blood Glucose - analysis; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Early Diagnosis; Fasting - blood; Female; Glucose; Humans; Insulin resistance; Internal Medicine; Male; Middle Aged; Prevention; Risk factor; Triglycerides; Triglycerides - blood; Type 2 diabetes; Type 2 diabetes; LDL-C; ROC; TyG index; IR; HR; Triglycerides; IFG; Glucose; Lp(a); NFG; AUC; TC; HDL-C; Prevention; TG; Risk factor; VMCUN cohort; Insulin resistance; FPG; CUN; BMI; receiver operating characteristics; total cholesterol; impaired fasting glucose; Vascular-Metabolic CUN cohort; insulin resistance; normal fasting glucose; body mass index; University of Navarra Clinic; area under the curve; triglycerides; HDL cholesterol; triglyceride–glucose index; hazard ratio; fasting plasma glucose; LDL cholesterol; lipoprotein(a)
• ISSN: 0091-7435; 1096-0260; 1096-0260
• DOI: 10.1016/j.ypmed.2016.01.022

We evaluated the potential role of the triglyceride–glucose index (TyG index) as a predictor of diabetes in a White European cohort, and compared it to fasting plasma glucose (FPG) and triglycerides. 4820 patients of the Vascular-Metabolic CUN cohort (VMCUN cohort) were examined and followed up for 8.84years (±4.39). We performed a Cox proportional hazard ratio with repeated-measures analyses to assess the risk of developing type 2 diabetes across quartiles of FPG, triglycerides and the TyG index (ln[fasting triglycerides (mg/dl)×fasting plasma glucose (mg/dl)/2]), and plotted a receiver operating characteristics (ROC) curve for discrimination. There were 332 incident cases of type 2 diabetes involving 43,197.32person-years of follow-up. We observed a progressively increased risk of diabetes in subjects with TyG index levels of 8.31 or more. Among those with normal fasting glucose at baseline, <100mg/dl, subjects with the TyG index in the fourth quartile were 6.87 times more likely to develop diabetes (95% CI, 2.76–16.85; P for trend<0.001), as compared with the bottom quartile. The areas under the ROC curves (95% CI) were 0.75 (0.70–0.81) for TyG index, 0.66 (0.60–0.72) for FPG and 0.71 (0.65–0.77) for TG, in subjects with normal fasting glucose (p=0.017). Our data suggest that the TyG index is useful for the early identification of individuals at risk of type 2 diabetes. The TyG index seems to be a better predictor than FPG or triglycerides of the potential development of type 2 diabetes in normoglycemic patients. •TyG index was useful for the early identification of patients at risk of diabetes.•Triglyceride levels upper than 86mg/dl were a risk factor for developing diabetes.•A glucose level greater than 96mg/dl significantly increased diabetes risk.•TyG index was the best predictor of developing diabetes in normoglycemic patients.•More attention should be given to high triglyceride levels and diabetes risk.