Inducible costimulator ligand (ICOSL) on CD19+ B cells is involved in immunopathological damage of rheumatoid arthritis (RA)
Inducible costimulator (ICOS) and its ligand (ICOSL) are critical to regulate the immune response in autoimmune diseases. The participation of B lymphocytes exhibits pathogenic potential in the disease process of rheumatoid arthritis (RA). However, the precise role of ICOSL in RA remains unclear. In...
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Published in | Frontiers in immunology Vol. 13; p. 1015831 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
02.11.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Inducible costimulator (ICOS) and its ligand (ICOSL) are critical to regulate the immune response in autoimmune diseases. The participation of B lymphocytes exhibits pathogenic potential in the disease process of rheumatoid arthritis (RA). However, the precise role of ICOSL in RA remains unclear. In this study, we aimed to explore the regulatory effects of CD19
+
ICOSL
+
B cells in the pathogenesis of RA. We demonstrated the increased expression of ICOS and ICOSL in patients with RA and collagen-induced arthritis (CIA) mice. The population of CD19
+
ICOSL
+
B-cell subset was significantly correlated with clinicopathological characteristics of RA patients and CIA mice. Adoptive transfer of CD19
+
ICOSL
+
B cells aggravated arthritic progression in CIA mice. Moreover, microarray analysis revealed that CD19
+
ICOSL
+
cells could exert pivotal effect in pathological process of RA. Further blocking of ICOSL significantly inhibited proinflammatory responses and ameliorated arthritic progression. Therefore, CD19
+
ICOSL
+
B-cell subset could be defined as a specific pathogenic cell subpopulation involved in immunopathological damage of RA. Blockade of ICOSL is promising to be a potential new approach for RA therapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Shengjun Wang, Jiangsu University Affiliated People’s Hospital, China This article was submitted to Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders, a section of the journal Frontiers in Immunology These authors have contributed equally to this work and share first authorship Reviewed by: Jason Weinstein, Rutgers, The State University of New Jersey, United States; Umberto Dianzani, University of Eastern Piedmont, Italy |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2022.1015831 |