Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

• Published in: The New England journal of medicine Vol. 384; no. 21; pp. 1981 - 1990
• Main Authors: Jones, W. Schuyler, Mulder, Hillary, Wruck, Lisa M, Pencina, Michael J, Kripalani, Sunil, Muñoz, Daniel, Crenshaw, David L, Effron, Mark B, Re, Richard N, Gupta, Kamal, Anderson, R. David, Pepine, Carl J, Handberg, Eileen M, Manning, Brittney R, Jain, Sandeep K, Girotra, Saket, Riley, Danielle, DeWalt, Darren A, Whittle, Jeff, Goldberg, Ythan H, Roger, Veronique L, Hess, Rachel, Benziger, Catherine P, Farrehi, Peter, Zhou, Li, Ford, Daniel E, Haynes, Kevin, VanWormer, Jeffrey J, Knowlton, Kirk U, Kraschnewski, Jennifer L, Polonsky, Tamar S, Fintel, Dan J, Ahmad, Faraz S, McClay, James C, Campbell, James R, Bell, Douglas S, Fonarow, Gregg C, Bradley, Steven M, Paranjape, Anuradha, Roe, Matthew T, Robertson, Holly R, Curtis, Lesley H, Sharlow, Amber G, Berdan, Lisa G, Hammill, Bradley G, Harris, Debra F, Qualls, Laura G, Marquis-Gravel, Guillaume, Modrow, Madelaine F, Marcus, Gregory M, Carton, Thomas W, Nauman, Elizabeth, Waitman, Lemuel R, Kho, Abel N, Shenkman, Elizabeth A, McTigue, Kathleen M, Kaushal, Rainu, Masoudi, Frederick A, Antman, Elliott M, Davidson, Desiree R, Edgley, Kevin, Merritt, James G, Brown, Linda S, Zemon, Doris N, McCormick, Thomas E, Alikhaani, Jacqueline D, Gregoire, Kenneth C, Rothman, Russell L, Harrington, Robert A, Hernandez, Adrian F
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 27.05.2021
• Subjects: Aged; Arteriosclerosis; Aspirin; Aspirin - administration & dosage; Aspirin - adverse effects; Atherosclerosis - drug therapy; Bleeding; Call centers; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - mortality; Cardiovascular Diseases - prevention & control; Cerebral infarction; Clinical trials; Confidence intervals; Data models; Death; Design; Dosage; Electronic health records; Female; Heart attacks; Hemorrhage - chemically induced; Hospitalization; Humans; Internet; Male; Medication Adherence - statistics & numerical data; Middle Aged; Myocardial infarction; Myocardial Infarction - epidemiology; Myocardial Infarction - prevention & control; Patient safety; Patient-centered care; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Secondary Prevention; Statistical analysis; Stroke; Stroke - epidemiology; Stroke - prevention & control; Web portals
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2102137

In an open-label, pragmatic trial, patients with cardiovascular disease were randomly assigned to a strategy of 81 mg or 325 mg of aspirin daily. A substantial proportion of those assigned to the 325-mg dose switched to the 81-mg dose, and there were no significant differences in cardiovascular events or major bleeding between the two groups.