Curcumin in Treating Breast Cancer A Review

Breast cancer is among the most common malignant tumors. It is the second leading cause of cancer mortality among women in the United States. Curcumin, an active derivative from turmeric, has been reported to have anticancer and chemoprevention effects on breast cancer. Curcumin exerts its anticance...

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Bibliographic Details
Published inJournal of Laboratory Automation Vol. 21; no. 6; pp. 723 - 731
Main Authors Wang, Yiwei, Yu, Jiayi, Cui, Ran, Lin, Jinjin, Ding, Xianting
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.12.2016
Subjects
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological Products - pharmacology
Biological Products - therapeutic use
Breast Neoplasms - drug therapy
Curcumin - pharmacology
Curcumin - therapeutic use
Female
Humans
Signal Transduction - drug effects
United States
breast cancer
signaling pathways
natural compound
curcumin
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Summary:Breast cancer is among the most common malignant tumors. It is the second leading cause of cancer mortality among women in the United States. Curcumin, an active derivative from turmeric, has been reported to have anticancer and chemoprevention effects on breast cancer. Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways. Experimental evidence has shown that curcumin also regulates apoptosis and cell phase–related genes and microRNA in breast cancer cells. Herein, we review the recent research efforts in understanding the molecular targets and anticancer mechanisms of curcumin in breast cancer.
ISSN:2211-0682
2472-6303
1540-2452
2211-0690
DOI:10.1177/2211068216655524