Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population

• Published in: Journal of international medical research Vol. 43; no. 3; pp. 326 - 331
• Main Authors: Jia, Shasha, Dong, Wanli, Zhou, Xianju, Chen, Zhiguo, Yun, Wenwei
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2015
• Subjects: Adolescent; Adult; Aged; Asian Continental Ancestry Group - genetics; China; Ethnic Groups - genetics; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Migraine Disorders - epidemiology; Migraine Disorders - genetics; Polymorphism, Single Nucleotide - genetics; TNF-Related Apoptosis-Inducing Ligand - genetics; Young Adult; China; TNFSF10; susceptibility; Migraine; gene polymorphisms
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060514565681

Objective To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10. Methods Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis. Results Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine. Conclusion There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.