The role of transporters in drug interactions
Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected d...
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Published in | European journal of pharmaceutical sciences Vol. 27; no. 5; pp. 501 - 517 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.04.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro–in vivo correlation is important for predicting future transporter-based drug interactions. |
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ISSN: | 0928-0987 1879-0720 |
DOI: | 10.1016/j.ejps.2005.11.002 |