The role of transporters in drug interactions

• Published in: European journal of pharmaceutical sciences Vol. 27; no. 5; pp. 501 - 517
• Main Authors: Endres, Christopher J., Hsiao, Peng, Chung, Francisco S., Unadkat, Jashvant D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2006
• Subjects: Animals; Anti-Arrhythmia Agents - pharmacokinetics; Anti-Arrhythmia Agents - pharmacology; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - metabolism; Digoxin - pharmacokinetics; Drug Interactions; Drug transporters; Gemfibrozil - pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics; Hypolipidemic Agents - pharmacokinetics; Hypolipidemic Agents - pharmacology; In Vitro Techniques; In vitro–in vivo correlation; Kidney - drug effects; Kidney - metabolism; Liver - drug effects; Liver - metabolism; Membrane Transport Proteins - metabolism; Models, Biological; Organic Anion Transporters - antagonists & inhibitors; Organic Anion Transporters - metabolism; Organic Cation Transport Proteins - metabolism; Quinidine - pharmacology; Drug interactions; In vitro–in vivo correlation; Drug transporters
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/j.ejps.2005.11.002

Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro–in vivo correlation is important for predicting future transporter-based drug interactions.