Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study

• Published in: BMC endocrine disorders Vol. 24; no. 1; pp. 152 - 10
• Main Authors: Li, Zhuoya, Zhang, Jie, Jiang, Yizhou, Ma, Kai, Cui, Cheng, Wang, Xiaoyong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.08.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Body mass index; Cholesterol; Complication; Complications and side effects; Diabetes; Diabetes Complications - epidemiology; Diabetes Complications - microbiology; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetic nephropathies; Diabetic Nephropathies - complications; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - etiology; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Endoscopy; Female; Follow-Up Studies; Glucose; Glycated Hemoglobin - analysis; Glycated Hemoglobin - metabolism; Glycosylated hemoglobin; Helicobacter infections; Helicobacter Infections - complications; Helicobacter pylori; Helicobacter pylori - isolation & purification; Hemoglobin; Humans; Hyperglycemia; Hypertension; Infection; Infections; Male; Medical research; Medicine, Experimental; Middle Aged; Multivariate analysis; Nephropathy; Neuropathy; Peripheral neuropathy; Prognosis; Regression analysis; Retinopathy; Retrospective Studies; Risk factors; Type 2 diabetes; Vascular diseases; Type-2 diabetes; Complication; Nephropathy; Helicobacter pylori
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-024-01678-2

Previous studies examined the association of Helicobacter pylori infection (H. pylori) with complications of diabetes, but the results have been inconsistent. The aim of this study of patients with type-2 diabetes (T2D) was to determine the association of H. pylori infection with the major complications of diabetes. This single-center retrospective study examined patients with T2D who received H. pylori testing between January 2016 and December 2021. Logistic regression analyses were used to evaluate the association of H. pylori infection with four major complications of diabetes. We examined 960 patients with T2D, and 481 of them (50.1%) were positive for H. pylori. H. pylori infection was significantly associated with diabetic nephropathy (odds ratio [OR] = 1.462; 95% confidence interval [CI]: 1.006,2.126; P = 0.046). In addition, the co-occurrence of H. pylori positivity with hypertension (OR = 4.451; 95% CI: 2.351,8.427; P < 0.001), with glycated hemoglobin A1c (HbA1c) of at least 8% (OR = 2.925; 95% CI: 1.544,5.541; P = 0.001), and with diabetes duration of at least 9 years (OR = 3.305; 95% CI:1.823,5.993; P < 0.001) further increased the risk of diabetic nephropathy. There was no evidence of an association of H. pylori infection with retinopathy, neuropathy, or peripheral vascular disease. Our study of T2D patients indicated that those with H. pylori infections had an increased risk of nephropathy, and this risk was greater in patients who also had hypertension, an HbA1c level of 8% or more, and diabetes duration of 9 years or more.