Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation

• Published in: The Journal of experimental medicine Vol. 164; no. 5; pp. 1773 - 1778
• Main Authors: FRIEDMAN, S. M, JOVER, J. A, CHARTASH, E. K, CROW, M. K
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.11.1986; The Rockefeller University Press
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Antigens, Differentiation, B-Lymphocyte; Antigens, Surface - biosynthesis; B-Lymphocytes - immunology; Biological and medical sciences; Cell interactions; Cell Line; Fundamental and applied biological sciences. Psychology; Fundamental immunology; HLA-D Antigens - immunology; HLA-DR Antigens - immunology; Humans; Immunobiology; Lymphocyte Activation; Receptors, Antigen, T-Cell - physiology; T-Lymphocytes, Helper-Inducer - immunology; Trinitrobenzenes - immunology; Antigen; Human; Specificity; Immune response; Cell-cell interaction; Induction; Major histocompatibility system; Helper cell; Activation; B-Lymphocyte; T»-Lymphocyte
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.164.5.1773

We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.