Association of metabolic syndrome and its components with Parkinson's disease: a cross-sectional study

• Published in: BMC endocrine disorders Vol. 24; no. 1; pp. 92 - 8
• Main Authors: Shi, Yue, Zhang, XueYi, Feng, Yue, Yue, ZongXiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.06.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Alcohol; Algorithms; Analysis; Blood pressure; Coffee; Cross-Sectional Studies; Development and progression; Diabetes; Diabetes Mellitus; Disease; Diseases; Dopamine; Drug use; Female; Females; Glucose; Health surveys; Humans; Hyperlipidemia; Hypertension; Hypertension - complications; Hypertension - epidemiology; Male; Males; Medical research; Medicine, Experimental; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - epidemiology; Middle Aged; Missing data; Movement disorders; Neurodegenerative diseases; Nutrition Surveys; Parkinson Disease - complications; Parkinson Disease - epidemiology; Parkinson's disease; Population; Regression analysis; Risk Factors; Smoking; Surveys; Triglycerides; Type 2 diabetes; Womens health; United States > US; Hypertension; Parkinson’s Disease; Diabetes Mellitus; Metabolic syndrome
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-024-01623-3

The interrelation between metabolic syndrome (MetS) and Parkinson's disease (PD) likely arises from shared pathological mechanisms. This study thus aims to examine the impact of MetS and its components on PD. This study utilized data extracted from the National Health and Nutrition Examination Survey database spanning 1999 to 2020. The random forest algorithm was applied to fill in the missing data. Propensity score optimal full matching was conducted. The data were adjusted by total weights derived from both sampling and matching weights. The weighted data were utilized to create multifactor logistic regression models. Odds ratios (ORs) and average marginal effects, along with their corresponding 95% confidence intervals (CIs), were calculated. MetS did not significantly affect the risk of PD (OR: 1.01; 95% CI: 0.77, 1.34; P = 0.92). Hypertension elevated the risk of PD (OR: 1.33; 95% CI: 1.01, 1.76; P = 0.045), accompanied by a 0.26% increased probability of PD occurrence (95% CI: 0.01%, 0.52%; P = 0.04). Diabetes mellitus (DM) had a 1.38 times greater likelihood of developing PD (OR:1.38; 95% CI: 1.004, 1.89; P = 0.046), corresponding to a 0.32% increased probability of PD occurrence (95% CI: -0.03%, 0.67%; P = 0.07). Nevertheless, no correlation was observed between hyperlipidemia, waist circumference and PD. MetS does not affect PD; however, hypertension and DM significantly increase the risk of PD.