Long non-coding RNA SNHG7 serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after percutaneous coronary intervention

• Published in: Journal of cardiothoracic surgery Vol. 19; no. 1; pp. 450 - 7
• Main Authors: Liao, Ran, Han, Qing, Zhang, Li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.07.2024; BioMed Central; BMC
• Subjects: ACS; Acute Coronary Syndrome - diagnosis; Acute Coronary Syndrome - genetics; Acute Coronary Syndrome - surgery; Acute coronary syndromes; Aged; Angioplasty; Biomarkers; Biomarkers - metabolism; Cardiovascular disease; Diagnosis; Female; Humans; Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; PCI; Percutaneous Coronary Intervention; Predictive Value of Tests; Prognosis; Regression analysis; RNA; RNA, Long Noncoding - genetics; ROC Curve; SNHG7; Transluminal angioplasty; United States; Taiwan; China; ACS; Prognosis; Diagnosis; SNHG7; PCI
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-024-02855-z

Acute coronary syndrome (ACS) is one of the common causes of cardiovascular death. The related lncRNAs were novel approaches for early diagnosis and intervention. This paper focused on the clinical function of SNHG7 for patients after PCI. The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7. SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI. SNHG7 might be a diagnostic and prognostic tool for ACS patients.