Ferroptosis and its role in skeletal muscle diseases

Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products, which regulates physiological and pathological processes in numerous organs and tissues. A growing body of research suggests that ferroptosis is a key causative factor in a variety of skeletal muscle diseases,...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in molecular biosciences Vol. 9; p. 1051866
Main Authors Wang, Ying, Zhang, Zepeng, Jiao, Weikai, Wang, Yanyan, Wang, Xiuge, Zhao, Yunyun, Fan, Xuechun, Tian, Lulu, Li, Xiangyan, Mi, Jia
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.11.2022
Subjects
fatigue
ferroptosis
mechanism
Molecular Biosciences
rhabdomyolysis
rhabdomyosarcoma
sarcopenia
Online AccessGet full text

Cover

More Information
Summary:Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products, which regulates physiological and pathological processes in numerous organs and tissues. A growing body of research suggests that ferroptosis is a key causative factor in a variety of skeletal muscle diseases, including sarcopenia, rhabdomyolysis, rhabdomyosarcoma, and exhaustive exercise-induced fatigue. However, the relationship between ferroptosis and various skeletal muscle diseases has not been investigated systematically. This review’s objective is to provide a comprehensive summary of the mechanisms and signaling factors that regulate ferroptosis, including lipid peroxidation, iron/heme, amino acid metabolism, and autophagy. In addition, we tease out the role of ferroptosis in the progression of different skeletal muscle diseases and ferroptosis as a potential target for the treatment of multiple skeletal muscle diseases. This review can provide valuable reference for the research on the pathogenesis of skeletal muscle diseases, as well as for clinical prevention and treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Min Wan, Cornell University, United States
Enchao Qiu, Thomas Jefferson University, United States
These authors have contributed equally to this work
Edited by: Xin Wang, National Institutes of Health (NIH), United States
Xianyi Cai, Huazhong University of Science and Technology, China
This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2022.1051866