Correlation between the triglyceride-glucose index and left ventricular global longitudinal strain in patients with chronic heart failure: a cross-sectional study

• Published in: Cardiovascular diabetology Vol. 23; no. 1; pp. 182 - 12
• Main Authors: Zhang, Shuai, Liu, Yan, Liu, Fangfang, Ye, Qing, Guo, Dachuan, Xu, Panpan, Wei, Tianhao, Zhang, Cheng, Lu, Huixia
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.05.2024; BMC
• Subjects: Aged; Biomarkers - blood; Blood Glucose - metabolism; Blood pressure; Body mass index; Cardiovascular disease; Cholesterol; Chronic Disease; Chronic heart failure; Chronic illnesses; Congestive heart failure; Coronary vessels; Correlation analysis; Cross-Sectional Studies; Ejection fraction; Fasting; Female; Global Longitudinal Strain; Glucose; Heart failure; Heart Failure - blood; Heart Failure - diagnosis; Heart Failure - physiopathology; High density lipoprotein; Humans; Hyperlipidemia; Hypertension; Insulin Resistance; Lipids; Male; Medical diagnosis; Medical records; Middle Aged; Predictive Value of Tests; Prognosis; Side effects; Sleep apnea; Software; Statistical analysis; Stroke Volume; Triglyceride-glucose index; Triglycerides; Triglycerides - blood; Ultrasonic imaging; Variables; Ventricle; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left; United States > US; Triglyceride-glucose index; Global longitudinal strain; Chronic heart failure
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-024-02259-2

Left ventricular global longitudinal strain (GLS) holds greater diagnostic and prognostic value than left ventricular ejection fraction (LVEF) in the heart failure (HF) patients. The triglyceride-glucose (TyG) index serves as a reliable surrogate for insulin resistance (IR) and is strongly associated with several adverse cardiovascular events. However, there remains a research gap concerning the correlation between the TyG index and GLS among patients with chronic heart failure (CHF). 427 CHF patients were included in the final analysis. Patient demographic information, along with laboratory tests such as blood glucose, lipids profiles, and echocardiographic data were collected. The TyG index was calculated as Ln [fasting triglyceride (TG) (mg/dL) × fasting plasma glucose (FPG) (mg/dL)/2]. Among CHF patients, GLS was notably lower in the higher TyG index group compared to the lower TyG index group. Following adjustment for confounding factors, GLS demonstrated gradual decrease with increasing TyG index, regardless of the LVEF level and CHF classification. Elevated TyG index may be independently associated with more severe clinical left ventricular dysfunction in patients with CHF.