Metabolic syndrome in normal and complicated pregnancies

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 137; no. 2; pp. 178 - 184
• Main Authors: Bartha, José L, González-Bugatto, Fernando, Fernández-Macías, Rosa, González-González, Nieves L, Comino-Delgado, Rafael, Hervías-Vivancos, Blas
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.04.2008; Elsevier
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Glucose - metabolism; Blood Pressure - physiology; Cardiology. Vascular system; Cholesterol, HDL - blood; Diabetes, Gestational - diagnosis; Diabetes, Gestational - mortality; Diabetes, Gestational - physiopathology; Diseases of mother, fetus and pregnancy; Female; Gestational diabetes; Gestational hypertension; Gynecology. Andrology. Obstetrics; Humans; Hypertension, Pregnancy-Induced - diagnosis; Hypertension, Pregnancy-Induced - mortality; Hypertension, Pregnancy-Induced - physiopathology; Insulin resistance; Insulin Resistance - physiology; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Miscellaneous; Obstetrics and Gynecology; Other metabolic disorders; Preeclampsia; Pregnancy; Pregnancy complications; Pregnancy Complications - diagnosis; Pregnancy Complications - metabolism; Pregnancy Complications - physiopathology; Pregnancy. Fetus. Placenta; Prevalence; Triglycerides - blood; World Health Organization; Insulin resistance; Gestational diabetes; Metabolic syndrome; Preeclampsia; Gestational hypertension; Pregnancy complications; Endocrinopathy; Hypertension; Pregnancy disorders; Gynecology; Metabolic diseases; Cardiovascular disease; Maternal diseases; Insulin; Obstetrics; Pregnancy toxemia; Pregnancy; Target tissue resistance; Complication; Female
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2007.06.011

Abstract Objective To evaluate the prevalence of metabolic syndrome and its components in normal and complicated pregnancies. Study design Setting: university hospital, tertiary referral centre. Subjects: 90 pregnant women in four groups: 20 women with preeclampsia, 20 women with gestational hypertension, 30 women with late-onset gestational diabetes and 20 healthy pregnant women as a control group. Intervention: peripheral insulin resistance was measured by using the insulin tolerance test. Glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure and body mass index were analysed. Comparisons were done by Chi-squared test, one-way analysis of variance and the Bonferroni's test. Prevalence of the metabolic syndrome was calculated by adapting both the WHO and the NCEP definitions of the metabolic syndrome to pregnancy. Results There were no cases of metabolic syndrome in the control group according to any of the adapted definitions. The prevalence of this syndrome was 3.3% and 10% in the late-onset gestational diabetes group, 35% and 20% in the gestational hypertension group and 30% and 30% in the preeclampsia group for the WHO and the NCEP definitions, respectively. Conclusions Metabolic syndrome is present in about one-third of women with pregnancy-induced hypertension but only in 10% of women with late-onset gestational diabetes.