In vitro activities of fourteen antimicrobial agents against obligately anaerobic bacteria

• Published in: International journal of antimicrobial agents Vol. 16; no. 3; pp. 225 - 232
• Main Authors: Schaumann, Reiner, Ackermann, Grit, Pless, Baerbel, Claros, Marina C, Goldstein, Ellie J.C, Rodloff, Arne C
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01.11.2000; Amsterdam Elsevier; New York, NY
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial agents; Bacteria, Anaerobic - drug effects; Biological and medical sciences; Broth microdilution technique; Humans; Medical sciences; MIC; Microbial Sensitivity Tests; Obligately anaerobic bacteria; Pharmacology. Drug treatments; Broth microdilution technique; Antimicrobial agents; Obligately anaerobic bacteria; MIC; Anaerobiosis; Antibiotic; Dilution; Minimum inhibitory concentration; Bacteria; Antibacterial agent; In vitro; Biological activity; Microassay; Microbiological method
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/S0924-8579(00)00186-2

The in vitro activities of fourteen antimicrobial agents were tested against 292 clinical isolates of obligately anaerobic bacteria using the broth microdilution technique. Taking all strains as a group the MIC 50/90 (mg/l) values were metronidazole and imipenem 0.25/1, meropenem 0.25/0.5, trovafloxacin 0.25/1, gatifloxacin and moxifloxacin 0.5/2, levofloxacin 2/16, ciprofloxacin 4/32, clindamycin 0.5/8, amoxycillin/clavulanate 1/4, doxycycline and chloramphenicol 2/4, erythromycin 4/>32 and penicillin G 16/>32.