Transfusion Volume for Children with Severe Anemia in Africa

This open-label trial randomly assigned African children 2 months to 12 years of age with severe anemia to receive immediate blood transfusion with 20 ml per kilogram or 30 ml per kilogram. The primary outcome of 28-day mortality did not differ between transfusion-volume strategies.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 381; no. 5; pp. 420 - 431
Main Authors Maitland, Kathryn, Olupot-Olupot, Peter, Kiguli, Sarah, Chagaluka, George, Alaroker, Florence, Opoka, Robert O, Mpoya, Ayub, Engoru, Charles, Nteziyaremye, Julius, Mallewa, Macpherson, Kennedy, Neil, Nakuya, Margaret, Namayanja, Cate, Kayaga, Julianna, Uyoga, Sophie, Kyeyune Byabazaire, Dorothy, M’baya, Bridon, Wabwire, Benjamin, Frost, Gary, Bates, Imelda, Evans, Jennifer A, Williams, Thomas N, Saramago Goncalves, Pedro, George, Elizabeth C, Gibb, Diana M, Walker, A. Sarah
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 01.08.2019
Subjects
Anemia
Anemia - complications
Anemia - mortality
Anemia - therapy
Blood & organ donations
Blood transfusion
Blood Transfusion - economics
Body weight
Child
Child, Preschool
Children
Cost analysis
Cost control
Cost-Benefit Analysis
Female
Fever
Fever - complications
Follow-Up Studies
Health Care Costs
Hemoglobin
Hemoglobins - analysis
Hospitalization
Hospitals
Humans
Infant
Length of Stay - economics
Malaria
Malaria - complications
Malawi - epidemiology
Male
Medical research
Micronutrients
Mortality
Patient Readmission - statistics & numerical data
Prophylaxis
Scholarships & fellowships
Sickle cell disease
Sulfamethoxazole
Transfusion Reaction - epidemiology
Trimethoprim
Uganda - epidemiology
Malawi
Uganda
United Kingdom > UK
Africa
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Summary:This open-label trial randomly assigned African children 2 months to 12 years of age with severe anemia to receive immediate blood transfusion with 20 ml per kilogram or 30 ml per kilogram. The primary outcome of 28-day mortality did not differ between transfusion-volume strategies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
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Members of the TRACT group are listed in the Supplementary Appendix, available with the full text of this article at NEJM.org.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1900100