Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due...

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Published inFrontiers in microbiology Vol. 13; p. 1025605
Main Authors Xu, Lin, Zhong, Xuan-Lei, Xi, Zhi-Chao, Li, Yang, Xu, Hong-Xi
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 10.10.2022
Subjects
acyclovir-resistant
antiviral herbs
herpes simplex virus
Microbiology
mode of action
natural products
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Summary:Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Reviewed by: Qinchang Zhu, Shenzhen Technology University, China; Xun Song,Shenzhen University, China
These authors have contributed equally to this work
Edited by: Maria Teresa Sciortino, University of Messina, Italy
This article was submitted to Virology, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.1025605