Roles and crosstalks of macrophages in diabetic nephropathy

Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of glucose and metabolites activates resident macrophages in kidneys. Resident macrophages play diverse roles on diabetic kidney injuries by releasing cytokines/chemokines, recruiting peripheral monocytes/macrophages,...

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Published inFrontiers in immunology Vol. 13; p. 1015142
Main Authors Li, Hai-Di, You, Yong-Ke, Shao, Bao-Yi, Wu, Wei-Feng, Wang, Yi-Fan, Guo, Jian-Bo, Meng, Xiao-Ming, Chen, Haiyong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 02.11.2022
Subjects
diabetic nephropathy
fibrosis
Immunology
inflammation
macrophage
metabolic disorder
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Summary:Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of glucose and metabolites activates resident macrophages in kidneys. Resident macrophages play diverse roles on diabetic kidney injuries by releasing cytokines/chemokines, recruiting peripheral monocytes/macrophages, enhancing renal cell injuries (podocytes, mesangial cells, endothelial cells and tubular epithelial cells), and macrophage-myofibroblast transition. The differentiation and cross-talks of macrophages ultimately result renal inflammation and fibrosis in DN. Emerging evidence shows that targeting macrophages by suppressing macrophage activation/transition, and macrophages-cell interactions may be a promising approach to attenuate DN. In the review, we summarized the diverse roles of macrophages and the cross-talks to other cells in DN, and highlighted the therapeutic potentials by targeting macrophages.
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Reviewed by: Christoph Daniel, University Hospital Erlangen, Germany; Yafeng Li, The Fifth Hospital of Shanxi Medical University, China; Guochun Chen, Department of Nephrology, Central South University, China
These authors have contributed equally to this work
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Edited by: Yingmei Feng, Beijing Youan Hospital, Capital Medical University, China
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.1015142