Comparison of effectiveness and safety of camrelizumab between HBV-related and non-B, non-C hepatocellular carcinoma: A retrospective study in China
Purpose: This study aimed to compare the clinical outcomes of camrelizumab in hepatitis B virus-related hepatocellular carcinoma (HBV–HCC) patients and non-HBV, non-HCV hepatocellular carcinoma (NBNC–HCC) patients in China. Materials and methods: A total of 54 patients with hepatocellular carcinoma...
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Published in | Frontiers in genetics Vol. 13; p. 1000448 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
09.09.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose:
This study aimed to compare the clinical outcomes of camrelizumab in hepatitis B virus-related hepatocellular carcinoma (HBV–HCC) patients and non-HBV, non-HCV hepatocellular carcinoma (NBNC–HCC) patients in China.
Materials and methods:
A total of 54 patients with hepatocellular carcinoma who received camrelizumab were included in this retrospective study from January 2019 to December 2021. The patients were assigned to the HBV–HCC group (
n
= 28) and the NBNC–HCC group (
n
= 26). The primary endpoints were overall survival (OS) and progression-free survival (PFS), and the secondary endpoints were the objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). Multivariate analysis using Cox proportional hazard regression was used to identify independent prognostic factors. A nomogram model was subsequently established based on independent prognostic factors.
Results:
The mean duration of follow-up was 12.7 ± 3.6 months. The median OS was not determined. The median PFS in the HBV–HCC group was significantly longer than that in the NBNC–HCC group (9.2 vs. 6.7 months,
p
= 0.003). The ORR and DCR in the HBV–HCC group were significantly higher than those in the NBNC–HCC group (ORR, 28.6% vs. 7.7%,
p
= 0.048; DCR, 71.4% vs. 42.3%,
p
= 0.031). No significant differences in the total incidence of AEs were found between the HBV–HCC group and the NBNC–HCC group (75.0% vs. 69.2%,
p
= 0.224). Multivariate regression analysis identified etiology, AFP level, and vascular invasion as independent prognostic factors (all
p
< 0.05).
Conclusion:
Our findings demonstrate that camrelizumab is more effective in HBV–HCC patients than in NBNC–HCC patients, with manageable safety. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 RuiJin Xie, Affiliated Hospital of Jiangnan University, China Zijian Zhou, Huashan Hospital, Fudan University, China Edited by: Chang Gu, Tongji University, China Reviewed by: Changle Ji, Tongji University, China These authors have contributed equally to this work and share first authorship. This article was submitted to Cancer Genetics and Oncogenomics, a section of the journal Frontiers in Genetics |
ISSN: | 1664-8021 1664-8021 |
DOI: | 10.3389/fgene.2022.1000448 |