Human embryo implantation

Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the uterine mucosa into the underlying inner myometrium. Once implanted, embryo survival pivots on the transformation of the endometrium into an anti-...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 150; no. 10
Main Authors Muter, Joanne, Lynch, Vincent J, McCoy, Rajiv C, Brosens, Jan J
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 15.05.2023
Subjects
Embryo Implantation
Embryo, Mammalian - physiology
Endometrium - physiology
Female
Humans
Placenta
Pregnancy
Review
Uterus
Pregnancy
Aneuploidy
Implantation
Uterine remodelling
Decidualisation
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Summary:Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the uterine mucosa into the underlying inner myometrium. Once implanted, embryo survival pivots on the transformation of the endometrium into an anti-inflammatory placental bed, termed decidua, under homeostatic control of uterine natural killer cells. Here, we examine the evolutionary context of embryo implantation and elaborate on uterine remodelling before and after conception in humans. We also discuss the interactions between the embryo and the decidualising endometrium that regulate interstitial implantation and determine embryo fitness. Together, this Review highlights the precarious but adaptable nature of the implantation process.
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The authors declare no competing or financial interests.
Competing interests
ISSN:0950-1991
1477-9129
DOI:10.1242/dev.201507