Examining the relationships between adverse childhood experiences (ACEs), cortisol, and inflammation among young adults

Adverse childhood experiences (ACEs) are associated with dysregulation of inflammation and cortisol. The objectives of this study were to use principal component analysis to explore the inflammatory biomarker data to create inflammation composite variables; to examine the relationship between these...

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Published inBrain, behavior, & immunity. Health Vol. 25; p. 100516
Main Authors Wong, Kingston E., Wade, Terrance J., Moore, Jessy, Marcellus, Ashley, Molnar, Danielle S., O'Leary, Deborah D., MacNeil, Adam J.
Format Journal Article
LanguageEnglish
Published Elsevier 01.11.2022
Subjects
ACEs
Adverse childhood experiences
Biomarkers
Cortisol
Full Length
Inflammation
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Summary:Adverse childhood experiences (ACEs) are associated with dysregulation of inflammation and cortisol. The objectives of this study were to use principal component analysis to explore the inflammatory biomarker data to create inflammation composite variables; to examine the relationship between these composite measures of inflammation with ACEs and cortisol; and to assess whether these relationships were moderated by sex. The analysis included 232 young adults from the Niagara Longitudinal Heart Study (NLHS). After adjusting for covariates, higher exposure to ACEs significantly predicted higher low-grade inflammation. These results further support the use of multiple biomarkers to understand the complex relationships among ACEs, cortisol, and inflammation, which should be further examined in longitudinal studies to study biomarker trajectories.
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ISSN:2666-3546
2666-3546
DOI:10.1016/j.bbih.2022.100516