Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients

Hashimoto's encephalopathy (HE) is thought to be caused by disorders of immune mechanisms. Although immunologically mediated central nervous system vasculitis or unidentified anti-neuronal autoantibodies have been suspected of causing HE, its pathogenesis is still unclear. For the study present...

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Published inJournal of the neurological sciences Vol. 217; no. 1; pp. 7 - 12
Main Authors Oide, Takashi, Tokuda, Takahiko, Yazaki, Masahide, Watarai, Megumi, Mitsuhashi, Shigeaki, Kaneko, Kazuma, Hashimoto, Takao, Ohara, Shinji, Ikeda, Shu-ichi
Format Journal Article
LanguageEnglish
Published Shannon Elsevier B.V 15.01.2004
Elsevier Science
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Summary:Hashimoto's encephalopathy (HE) is thought to be caused by disorders of immune mechanisms. Although immunologically mediated central nervous system vasculitis or unidentified anti-neuronal autoantibodies have been suspected of causing HE, its pathogenesis is still unclear. For the study presented here, two patients with typical clinical and laboratory/electrophysiological findings of HE were analyzed to clarify the role of anti-neuronal autoantibodies in the pathogenesis of HE. The autopsied brain of one of the patients was histopathologically examined. For Western blotting analysis and immunohistochemistry, serum and purified immunoglobulin G obtained from the other patient were used. Autopsy revealed no evidence of central nervous system vasculitis or other abnormal findings in the brain. The patient's serum contained an anti-neuronal autoantibody that immunohistochemically labeled neurons of mouse and human cerebral cortices and reacted with the 36-kDa antigenic protein present in a soluble fraction obtained from human cerebral cortex. Our results indicate that anti-neuronal autoantibodies may be associated with the pathogenesis of HE.
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ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2003.08.005