Evaluation of the effect of chiropractic manipulative treatment on oxidative stress in sacroiliac joint dysfunction

• Published in: Turkish journal of physical medicine and rehabilitation Vol. 66; no. 2; pp. 176 - 183
• Main Authors: Okumus, Muyesser, Dogan, Murat, Neselioglu, Salim, Erel, Ozcan, Kultur, Turgut, Arikan Durmaz, Senay, Ciftci, Aydin
• Format: Journal Article
• Language: English; Turkish
• Published: Turkey Galenos Yayinevi Tic. Ltd 01.06.2020; Bayçınar Medical Publishing
• Subjects: Albumin; Analysis; Original; Oxidative stress; Thiols; manipulative treatment; sacroiliac joint dysfunction; thiol/disulphide homeostasis; ischemia-modified albumin; Chronic pain
• ISSN: 2587-0823; 1302-0234; 2587-0823
• DOI: 10.5606/TFTRD.2020.3301

This study aims to investigate the effect of chiropractic manipulative treatment on sacroiliac joint dysfunction (SIJD) and its relationship to oxidative stress (OXS) parameters. Thirty-three patients diagnosed with SIJD (20 males, 13 females; mean age 36.3±9.7 years; range, 18 to 60 years) and 30 healthy volunteers (20 males, 10 females; mean age 36.4±12.2 years; range, 20 to 57 years) were included in this cross-sectional, case-control study conducted between February 2017 and September 2017. Manipulation was applied to the patients once a week for a duration of four weeks. The patients were evaluated at pre-treatment and one month after treatment with visual analog scale, SIJD test, and total thiol, native thiol, disulphide, and ischemia-modified albumin (IMA) as OXS indicators. Prior to treatment, we demonstrated that serum native thiol (μmol/L) and total thiol (μmol/L) levels in the patient group were lower compared to control subjects (p=0.03 and p=0.02, respectively). Serum IMA levels were higher in the patient group (p=0.01). There was no change in OXS parameters after manipulative treatment in the patient group. Manipulation is useful in SIJD. Thiol/disulphide homeostasis and serum IMA levels may be used to measure the OXS in patients with SIJD.