A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions

Polycystic ovary syndrome (PCOS) affects up to 20% of women but remains poorly understood. It is a heterogeneous condition with many potential comorbidities. This review offers an overview of the dysregulation of the reproductive and metabolic systems associated with PCOS. Review of the literature i...

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Published inFrontiers in endocrinology (Lausanne) Vol. 13; p. 1017468
Main Authors Emanuel, Rebecca H. K., Roberts, Josh, Docherty, Paul D., Lunt, Helen, Campbell, Rebecca E., Möller, Knut
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 15.11.2022
Subjects
endocrine
Endocrinology
hormones
metabolic
PCOS
reproductive
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Summary:Polycystic ovary syndrome (PCOS) affects up to 20% of women but remains poorly understood. It is a heterogeneous condition with many potential comorbidities. This review offers an overview of the dysregulation of the reproductive and metabolic systems associated with PCOS. Review of the literature informed the development of a comprehensive summarizing ‘wiring’ diagram of PCOS-related features. This review provides a justification for each diagram aspect from the relevant academic literature, and explores the interactions between the hypothalamus, ovarian follicles, adipose tissue, reproductive hormones and other organ systems. The diagram will provide an efficient and useful tool for those researching and treating PCOS to understand the current state of knowledge on the complexity and variability of PCOS.
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This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology
Reviewed by: Stefano Palomba, Magna Græcia University, Italy; Barbara Obermayer-Pietsch, Medical University of Graz, Austria
Edited by: Kok-Min Seow, Shin Kong Wu Ho-Su Memorial Hospital, Taiwan
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.1017468