The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Rec...

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Published inFrontiers in cell and developmental biology Vol. 10; p. 1011371
Main Authors Zhao, Hanxiao, Li, Li, Zhao, Ning, Lu, Aiping, Lu, Cheng, He, Xiaojuan
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.10.2022
Subjects
Cell and Developmental Biology
cells
ceRNA
joint destruction
lncRNAs
rheumatoid arthritis
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Summary:Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.
Bibliography:ObjectType-Article-2
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Reviewed by: Sien Lin, The Chinese University of Hong Kong, Hong Kong SAR, China
Yajun Yang, Guangdong Medical University, China
Edited by: Denghui Xie, Southern Medical University, China
ZeYu Huang, Sichuan University, China
This article was submitted to Molecular and Cellular Pathology, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.1011371