Total Synthesis and Stereochemical Assignment of Myriaporones 1, 3, and 4
Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late‐stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these c...
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Published in | Angewandte Chemie (International ed.) Vol. 43; no. 13; pp. 1728 - 1730 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
19.03.2004
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late‐stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds. |
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Bibliography: | ark:/67375/WNG-W8JZZVZF-W istex:B0B4A66B569FB172B72FD9CCB626E0DB6C578467 ArticleID:ANIE200353348 Support was provided by the National Cancer Institute/National Institutes of Health (CA81128). K.N.F. thanks the University of Notre Dame for support through a J. Peter Grace Prize Fellowship and Searle Fellowship. Professor Kenneth Rinehart is acknowledged for providing spectra of authentic material. Medline NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200353348 |