Enzymatic Synthesis of Redox-Labeled RNA and Dual-Potential Detection at DNA-Modified Electrodes

Ferrocene and anthraquinone were used to label RNA (red, dark blue), which could then be detected at an electrode surface bearing complementary DNA oligonucleotide probes (light blue). This approach is an electrochemical analog of popular fluorescence methods for gene expression analysis.

Saved in:
Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 43; no. 21; pp. 2809 - 2812
Main Authors Di Giusto, Daniel A., Wlassoff, Wjatschesslaw A., Giesebrecht, Susanne, Gooding, J. Justin, King, Garry C.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 17.05.2004
WILEY‐VCH Verlag
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Ferrocene and anthraquinone were used to label RNA (red, dark blue), which could then be detected at an electrode surface bearing complementary DNA oligonucleotide probes (light blue). This approach is an electrochemical analog of popular fluorescence methods for gene expression analysis.
Bibliography:This work was supported by the Australian Research Council (grant LP0347371).
ark:/67375/WNG-X2KVLM4V-R
ArticleID:ANIE200352977
istex:3F4EE8C8D96090A6E5AF72583F50C64B2170F470
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352977