Progress in vaccine development for infectious diseases—a Keystone Symposia report

• Published in: Annals of the New York Academy of Sciences Vol. 1524; no. 1; pp. 65 - 86
• Main Authors: Cable, Jennifer, Graham, Barney S., Koup, Richard A., Seder, Robert A., Karikó, Katalin, Pardi, Norbert, Barouch, Dan H., Sharma, Bhawna, Rauch, Susanne, Nachbagauer, Raffael, Forsell, Mattias N. E., Schotsaert, Michael, Ellebedy, Ali H., Loré, Karin, Irvine, Darrell J., Pilkington, Emily, Tahtinen, Siri, Thompson, Elizabeth A., Feraoun, Yanis, King, Neil P., Saunders, Kevin, Alter, Galit, Moin, Syed M., Sliepen, Kwinten, Karlsson Hedestam, Gunilla B., Wardemann, Hedda, Pulendran, Bali, Doria‐Rose, Nicole A., He, Wan‐Ting, Juno, Jennifer A., Ataca, Sila, Wheatley, Adam K., McLellan, Jason S., Walker, Laura M., Lederhofer, Julia, Lindesmith, Lisa C., Wille, Holger, Hotez, Peter J., Bekker, Linda‐Gail
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2023
• Subjects: antigen design; Antigens; Communicable Diseases; COVID-19; COVID-19 - prevention & control; Humans; Immunology; Infectious diseases; Medicin och hälsovetenskap; Morbidity; mRNA vaccines; Pandemics; Pandemics - prevention & control; Public health; structural vaccinology; Vaccination; vaccine delivery; Vaccine Development; Vaccine efficacy; vaccine hesitancy; Vaccines; Vaccines - therapeutic use; vaccine hesitancy; mRNA vaccines; antigen design; vaccine delivery; structural vaccinology; vaccines
• ISSN: 0077-8923; 1749-6632; 1749-6632
• DOI: 10.1111/nyas.14975

The COVID‐19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies’ preparedness for future pandemics. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state‐of‐the‐art technologies, recent advancements in understanding vaccine‐mediated immunity, and new aspects of antigen design to aid vaccine effectiveness. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state‐of‐the‐art technologies, recent advancements in understanding vaccine‐mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.