Fragrance contact dermatitis: a worldwide multicenter investigation (Part II)

• Published in: Contact dermatitis Vol. 44; no. 6; pp. 344 - 346
• Main Authors: Larsen, Walter, Nakayama, Hideo, Fischer, Torkil, Elsner, Peter, Frosch, Peter, Burrows, Desmond, Jordan, William, Shaw, Stephanie, Wilkinson, John, Marks , Jr, James, Sugawara, M., Nethercott, Marc, Nethercott, James
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard International Publishers 01.06.2001; Blackwell
• Subjects: 1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexamethylcyclopenta‐γ‐2‐benzopyran; 1-citronellol; 8-hexahydro-4; 8-hexamethylcyclopenta-γ-2-benzopyran; Allergens - adverse effects; Allergens - chemistry; allergic contact dermatitis; Allergic diseases; Biological and medical sciences; Dermatitis, Allergic Contact - etiology; dimethyltetrahydrobenzaldehyde; Domestic and cosmetic products toxicology; fragrance; geranium oil bourbon; Humans; Immunopathology; jasmine absolute; Medical sciences; omega-6-hexadecenlactone; Patch Tests; Perfume - adverse effects; Perfume - chemistry; Sensitivity and Specificity; Skin allergic diseases. Stinging insect allergies; spearmint oil; Toxicology; α-amylcinnamaldehyde; Cosmetic; Human; Immunopathology; Allergy; Skin disease; Prevalence; Toxicity; Multicenter study; Perfume; Allergenicity; Epidemiology; Mixture; Contact dermatitis; Allergen
• ISSN: 0105-1873; 1600-0536
• DOI: 10.1034/j.1600-0536.2001.044006344.x

The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, l‐citronellol, spearmint oil, 1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexamethylcyclopenta‐γ‐2‐benzopyran, omega‐6‐hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and α‐amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).