Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus

Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti-dsDNA titer (expressed in units), and the C1q and C3 levels: when anti-dsDNA levels remained high, no exac...

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Bibliographic Details
Published inArthritis and rheumatism Vol. 22; no. 3; p. 226
Main Authors Swaak, A J, Aarden, L A, Statius van Eps, L W, Feltkamp, T E
Format Journal Article
LanguageEnglish
Published United States 01.03.1979
Subjects
Antibodies, Antinuclear - analysis
Centrifugation
Chemical Precipitation
Complement C1 - analysis
Complement C2 - analysis
DNA - immunology
DNA, Circular
DNA, Viral
Humans
Kidney - physiopathology
Kidney Function Tests
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Prognosis
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Summary:Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti-dsDNA titer (expressed in units), and the C1q and C3 levels: when anti-dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti-dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen.
ISSN:0004-3591
DOI:10.1002/art.1780220304