Novel diagnostics in renal transplantation

Renal transplantation is the treatment of choice for many patients with end stage renal disease. While significant progress has been achieved in short-term outcomes, long-term graft survival has only marginally improved. More than 50% of transplanted kidneys from deceased donors fail within 10 years...

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Published inChimerism Vol. 1; no. 2; pp. 69 - 73
Main Authors Kieran, Niamh E., Muczynski, Kimberly, Gadi, Vijayakrishna
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.10.2010
Landes Bioscience
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
Review
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Summary:Renal transplantation is the treatment of choice for many patients with end stage renal disease. While significant progress has been achieved in short-term outcomes, long-term graft survival has only marginally improved. More than 50% of transplanted kidneys from deceased donors fail within 10 years; and from living donors, within 12 years. A lack of clinical tools to accurately monitor the allograft is a major causative factor in this lack of progress. This paper discusses newly available methods used to assess allograft status with emphasis on the role of circulating chimerism in renal transplantation as a diagnostic indicator for rejection and injury.
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ISSN:1938-1956
1938-1964
DOI:10.4161/chim.1.2.14293